CBD and Pain Syndromes – A Literature Review
As stated, there a few mechanisms of action postulated for the positive analgesic effect of CBD including 1) proper regulation of a deficient endocannabinoid system, 2) Prominent anti-nociceptive 3) anti-inflammatory and 4) antioxidant effects. These properties have made CBD an ideal research candidate for many chronic pain syndromes. This includes, but is not limited to, rheumatoid arthritis, and various neuropathic pain syndromes such as chronic regional pain syndrome (CRPS), trigeminal neuralgia and post-herpetic neuralgia. In the most recent review of CRPS in 2017, researchers have identified in neuropathic pain models that the CB-2 receptor shows a high level of expression. CBD is considered a source of regulation of this overexpression and subsequent reduction of the neuropathic and inflammatory pain.